![]() They chose to examine both excitatory and inhibitory synapses, as most previous research had focused on only excitatory synapses. The research team, made up of scientists from the laboratories of David Freedman at UChicago and Narayanan “Bobby” Kasthuri at Argonne National Laboratory, leveraged recent advances in electron microscopy, as well as existing publicly available data sets, to compare the connectivity in both species. The results were published Sept. 14 in Cell Reports. Using artificial recurrent neural network modeling, the team was further able to determine that the metabolic cost of building and maintaining synapses likely drives larger neural networks to be sparser, as seen in primates versus mouse neurons. In a study comparing the brains of macaques and mice at the synaptic level, the researchers found that the primates had far fewer synapses per neuron compared to the rodents. But in a surprising finding, neuroscience researchers at the University of Chicago and Argonne National Laboratory have discovered that mice actually have more synapses connecting the neurons in their brains. ![]() Primates are generally considered “smarter” than mice. ![]()
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